August 2026– date –
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Backbone-Ionized Polymer iPβAE Quantitatively Guides Extra-Hepatic mRNA Expression to Spleen and Lung
Journal of the American Chemical Society USA Overview A study published in the Journal of the American Chemical Society introduces a backbone-ionized polymer (iPβAE) platform engineered for quantitatively guided extra-hepatic mRNA target... -
Asia-Pacific Revolutionizes Pharma Manufacturing: Surging Capabilities in HPAPIs, Biologics, and Advanced Therapies
BioProcess International Asia-Pacific Overview The Asia-Pacific (APAC) region is rapidly expanding its specialized pharmaceutical manufacturing capabilities beyond traditional APIs, focusing on high-value modalities like HPAPIs, ADCs, mR... -
AAV Vector Manufacturing Achieves Kilo-Scale Production with 2,000L+ Suspension Bioreactors, Solving Gene Therapy Bottleneck
Drug Discovery News USA Overview AAV upstream production has achieved significant scalability, with suspension bioreactors reaching over 2,000 liters using adapted HEK293 cells, providing volumetric capacity for clinical and commercial g... -
Tamarind Bio and GenScript Partner to Accelerate Drug Discovery by Connecting AI Molecular Design with Rapid Wet-Lab Validation
Facebook (from GenScript Biotech) USA Overview AI-driven drug design, particularly using generative models like GANs and VAEs, accelerates drug discovery by generating novel molecular structures with desired properties. These systems ana... -
Mannosylated Spleen-Targeted LNP (LNP-PAM) Enhances mRNA Delivery to Antigen-Presenting Cells, Overcoming Liver Tropism
ACS Publications USA Overview A novel mannosylated spleen-targeted lipid nanoparticle (LNP-PAM) has been developed to significantly enhance mRNA delivery to antigen-presenting cells by integrating active and endogenous targeting. This sy... -
Transferrin-Conjugated Polymeric Nanoparticles via PISA Enhance BBB Transport and Doxorubicin Delivery for Glioblastoma Therapy
ACS Publications USA Overview Researchers have developed transferrin-conjugated polymeric nanoparticles, synthesized via polymerization-induced self-assembly (PISA), for enhanced blood-brain barrier (BBB) penetration and glioblastoma (GB... -
Scaffold-Aware Transformer with Multi-Scale Attention Accelerates Novel Molecular Design
PMC (Part of MDPI) Switzerland Overview Researchers propose a novel framework for de novo molecular design that integrates a transformer-based generative model and a graph attention network-based predictive model, featuring a scaffold-aw... -
Structure-Aware AI Accelerates Next-Gen Drug Discovery: From 3D Molecular Geometry to Generative Biomolecular Design
Briefings in Bioinformatics | Oxford Academic UK Overview Structure-aware AI systems, leveraging graph neural networks, Transformer-based models, and diffusion-based generative models, are advancing next-generation drug discovery. These ... -
Montara Therapeutics Reimagines Blood-Brain Barrier as Solution, Not Problem, Secures $1M for Brain-Selective mTOR Therapy
Drug Discovery News USA Overview Montara Therapeutics is pioneering an approach to blood-brain barrier (BBB) drug delivery by leveraging the BBB to its advantage for brain-selective pharmacology. Instead of forcing drugs across, their te... -
Organ-on-Chip Platforms Accelerate Nanoparticle DDS Development: Revolutionizing Preclinical Predictive Power
Biophysics Reviews | AIP Publishing USA Overview While nanoparticle-based drug delivery systems (DDS) have advanced significantly, their preclinical evaluation's predictive power has been a bottleneck. The integration of nanoparticles wi...
