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Eli Lilly | Company Profile | iPS Cells & Regenerative Medicine

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COMPANY PROFILE / iPS CELLS & REGENERATIVE MEDICINE

Eli Lilly
A major drugmaker turning the cash it earns from obesity and diabetes into acquisitions in gene editing, gene therapy and in vivo CAR-T

Eli Lilly is not an iPS cell or regenerative medicine company. Its 2025 revenue was about US$65.2 billion, driven mainly by its obesity and diabetes medicines (Mounjaro and Zepbound). It appears in this series because it has been buying or acquiring, one after another, a therapy that rewrites genes directly (Verve Therapeutics, July 2025), an AAV gene therapy for an eye disease (Adverum Biotechnologies, December 2025) and therapies that make CAR-T cells inside the body (Orna, May 2026, and Kelonia, June 2026). These take a different road from regenerative medicine, which makes cells outside the body and returns them, and they point to competing approaches aimed at the same diseases. This article keeps the company-wide picture brief and focuses on what Lilly has bought in this field, and what is still at an early stage. It is not a recommendation of any treatment, only an organisation of the company's disclosures.

Sources: Eli Lilly's Form 10-K for the year ended 31 December 2025 (filed with the U.S. SEC on 12 February 2026), its Form 10-K for the year ended 31 December 2023, its Form 10-Q for the quarter ended 30 June 2026 (filed 5 August 2026), the statutory filings of the acquired companies Verve and Adverum, and ClinicalTrials.gov, used as primary material. Last updated October 2026.

What this article covers
  1. Lilly in 30 seconds, and where it stands in iPS cells and regenerative medicine
  2. The logo and how the name is written
  3. Where the company sits in the iPS cell and regenerative medicine field
  4. Scale
  5. Resources committed to this field
  6. What it has done so far
  7. What comes next
  8. What the company is aiming for
  9. Map of acquisitions and partnerships
  10. Technologies, products and services on offer
  11. The risks this company carries
  12. Glossary, references and claim-to-source audit

1. Eli Lilly in 30 seconds, and where it stands in iPS cells and regenerative medicine

LEGAL NAMEEli Lilly and CompanyCommonly called Lilly. Founded in 1901 (an Indiana corporation)
HEADQUARTERSIndianapolis, Indiana,
United States
Lilly Corporate Center
LISTINGNew York Stock Exchange
LLY
About 50,000 employees (end of 2025)
MAIN TYPELarge pharma & strategic partnersSecondary type: genome editing & gene therapy (entered through acquisitions)
HOW THE THERAPY WORKSGene editing (to the liver via LNP)
AAV / in vivo CAR-T
No iPS cell work is described in the 10-K or 10-Q
LARGEST ACQUISITIONKelonia
(in vivo CAR-T)
June 2026. Fair value at acquisition: US$4.897 billion
GENE EDITINGVerve TherapeuticsJuly 2025. US$549 million in cash (net of cash acquired) plus a CVR of up to about US$300 million
MOST ADVANCED PRODUCTIxo-vec (AAV)
Phase 3
From Adverum. Neovascular age-related macular degeneration
The one thing to grasp first

Lilly's strengths are financial power and a sales network. Gene editing, gene therapy and in vivo CAR-T were not built from scratch in house but brought in by acquisition Sourced. What is more, most of the products it has taken on are in early clinical stages (Phase 1 to 2) or preclinical, and the words "iPS cell" do not appear in the 10-K or 10-Q. Lilly's moves are therefore best read not as evidence that cell therapies made from iPS cells are spreading, but as evidence that a major drugmaker is putting money into a different approach, in which genes are rewritten inside the body, or immune cells are made inside the body, without making cells outside it. For more, see our explainers on genome editing, lipid nanoparticles, viral vectors and CAR-T cells.

2. The logo and how the name is written

A note on names: the legal entity is Eli Lilly and Company (the formal name) and its common name is Lilly. Its registrant name on EDGAR is "ELI LILLY & Co". This article covers the U.S. parent company, not its Japanese subsidiary. The logo is the script-style "Lilly" shown on the company's official website.

Official site: https://www.lilly.com/

3. Where the company sits in the iPS cell and regenerative medicine field

Three types of company in iPS cells and regenerative medicine All are "regenerative medicine" companies, yet each aims to cure in a completely different way Large pharma & strategic partners Genome editing & gene therapy iPS cell & cell therapy Enter via deals; own sales networks Rewrite genes directly to treat Make cells and transplant them Vertex / Novartis Bristol Myers Squibb and others CRISPR Therapeutics / Intellia Beam / Prime Medicine and others Fate / Sana Cuorips / Heartseed and others Funding for late stage and sales Editing tools, safety know-how Cell manufacturing and QC at scale Own cell and gene base is thin Hostage to partners' strategy Heavy cost and long-term safety Big pharma. Gene editing, AAV and in vivo CAR-T were bought in; iPS cells are not part of it Verve, Adverum, Orna and Kelonia were acquired in 2025 and 2026; most are at an early clinical stage
Fig. 1 The three types of company in iPS cells and regenerative medicine, and where Lilly sits. The classification is our own, and the companies shown are examples drawn from those covered in this series Our calculation. Lilly is mainly a large pharmaceutical company, with genome editing and gene therapy as a secondary type brought in through acquisitions (10-K and 10-Q).

Lilly is placed mainly on the left of Fig. 1 (large pharma & strategic partners), with the middle (genome editing & gene therapy) highlighted as secondary. Its mechanisms of treatment break down as follows Sourced.

MechanismWhat Lilly hasStatus
Genome editing (to the liver via LNP)VERVE-102 (PCSK9 gene), a Lp(a) editing programme (from the Verve collaboration)VERVE-102 is in Phase 1b, with Phase 2 due to start in October 2026
Gene delivery with AAVIxo-vec (neovascular age-related macular degeneration). Earlier acquisitions (from Prevail and Akouos)Ixo-vec is in Phase 3
In vivo CAR-TKLN-1010 (Kelonia, multiple myeloma), ORN-252 (Orna, CD19, autoimmune disease)Both in Phase 1
iPS cell-derived cells-Not described in the 10-K or 10-Q
Autologous / allogeneic cell therapy, mesenchymal stem cells-Not described in the 10-K or 10-Q (no cell therapy that processes cells outside the body appears among the main pipeline products)

4. Scale

Lilly is a large pharmaceutical company, so the whole-company picture is limited to one table. Amounts are in US$ million and the fiscal year ends in December Sourced.

Measure (US$ million)202320242025
Revenue-45,04365,179
Net income-10,59020,640
R&D expenses9,31310,99113,337
Acquired in-process R&D (expensed)-3,2802,910
Capital expenditure-5,1007,800

Revenue rose 45% in 2025, mainly because of the diabetes and obesity medicines Mounjaro and Zepbound (10-K). Lilly has about 50,000 employees (about 27,000 outside the United States), of whom about 12,000 work in R&D.

A caution

The figures above are for the company as a whole. Dedicated R&D spending and headcount for gene editing, gene therapy and in vivo CAR-T are not disclosed Not yet confirmed. How much of the US$13.3 billion of R&D expenses goes to this field is unknown. In the risk section of its 10-K, the company also notes that it depends on a small number of products or product groups for a large share of its revenue.

5. Resources committed to this field

ResourceWhat it isCategory
People (sites and staff)About 50,000 staff company-wide, about 12,000 of them in R&D. The number dedicated to genetic medicines is not disclosedSourced / dedicated headcount not confirmed
Money (manufacturing capital expenditure)Capital expenditure was US$7.8 billion in 2025 (US$5.1 billion in 2024), described as investment in facilities around the world to make current and future products. Capital expenditure for genetic medicines is not disclosedSourced / amount not confirmed
Outside investment and acquisitionsPrevail (January 2021: US$747.4 million in cash plus a CVR of up to about US$160 million); Akouos (December 2022: US$327.2 million in cash plus a CVR of up to about US$122 million); Verve (July 2025: US$549 million in cash plus a CVR of up to about US$300 million); Adverum (December 2025); Orna (May 2026: US$1.233 billion of acquired in-process R&D); Kelonia (June 2026: fair value of US$4.897 billion)Sourced
In-licensing and collaborationsA five-year research collaboration with Verve (June 2023, in vivo gene editing targeting Lp(a)). The first development candidate of the collaboration was selected between January and March 2025, and Verve received a US$20 million milestone. Lilly had an option to opt in to the PCSK9 programme. Acquired in July 2025Sourced (from Verve's 10-Q)
Universities, research institutions and public fundingNot described in Lilly's own 10-K or 10-Q. The 10-Q of the acquired company Verve describes intellectual property licences from Harvard, the Broad Institute, Beam Therapeutics and NovartisNot confirmed (Lilly's side) / Verve's side is Sourced
How to read the acquisition prices

A CVR (contingent value right) is additional consideration paid only if a specific result is achieved. Verve's CVR is up to US$3.00 per share (up to about US$300 million in total), and Adverum's is up to US$8.91 per share (if both conditions are met). Both are ceilings that apply if the milestones are reached, not confirmed payments Sourced. For Kelonia, too, the June 2026 10-Q records contingent consideration of up to US$3.75 billion, whose fair value at acquisition was estimated at US$1.765 billion. When quoting these numbers, "confirmed amounts" and "ceiling amounts" need to be read separately.

6. What it has done so far

WhenWhat happenedWhy it matters
January 2021Acquires Prevail Therapeutics: AAV9-based gene therapies for neurodegenerative disease (PR001, PR006)The starting point of Lilly's gene therapy. Described as a "new modality"
December 2022Acquires Akouos: gene therapy for inner-ear conditions such as hearing lossExtension of gene therapy to the ear
June 2023Five-year research collaboration with Verve (in vivo gene editing targeting Lp(a))Lilly's first involvement in genome editing
March 2025Verve: the FDA accepts the IND (investigational new drug application) for VERVE-102 and grants Fast Track designation. The collaboration's first development candidate is selected, triggering a US$20 million milestone. Verve says it expects to submit the PCSK9 opt-in package to LillyThe collaboration moves to the product stage
16 June to July 2025Signs a merger agreement for Verve and acquires it through a tender offer (US$10.50 per share plus a CVR of up to US$3.00)Buys a genome editing company outright
24 October to 9 December 2025Signs a merger agreement for Adverum and acquires it through a tender offer (US$3.56 per share plus a CVR of up to US$8.91). Obtains Ixo-vecAcquires a Phase 3 product in AAV gene therapy
May 2026Acquires the assets of Orna Therapeutics (ORN-252, in vivo CAR-T targeting CD19, Phase 1). Acquired in-process R&D of US$1.233 billionIn vivo CAR-T for autoimmune disease
25 June 2026Acquires Kelonia Therapeutics (in vivo CAR-T, KLN-1010). Fair value at acquisition: US$4.897 billionA serious investment in in vivo CAR-T

A caution on reading the early VERVE-102 data

In April 2025, before its acquisition, Verve announced data on 14 patients in the Heart-2 study (Phase 1b), with a data cut-off of 13 March 2025. After a single dose, the mean reduction in blood LDL cholesterol in the highest-dose group (0.6 mg/kg, 4 patients) was 53%, time-averaged from day 28 after dosing to the last follow-up. However, this was an early, open-label, dose-escalation study with no comparison against a control group. Its primary endpoint is safety (adverse events), and efficacy is a secondary check. Gene editing is an irreversible change, and long-term safety has yet to be tested. This article does not recommend any particular treatment.

7. What comes next

ProductStatus (ClinicalTrials.gov and the 10-K and 10-Q)Category
VERVE-102 (PCSK9)Phase 1b Heart-2 (NCT06164730, estimated 85 participants, primary endpoint adverse events, estimated primary completion October 2026). Phase 2 (NCT07839936, estimated 175 participants, primary endpoint percentage change in LDL-C at 90 days, due to start in October 2026, estimated primary completion August 2028)In development (Phase 1b to 2). Timing of approval: Not yet confirmed
Ixo-vec (AAV, neovascular AMD)Phase 3 ARTEMIS (NCT06856577, 311 participants, primary endpoint average change in visual acuity at weeks 52 and 56, estimated primary completion December 2026). AQUARIUS (NCT07482176, estimated 534 participants, started March 2026)In development (Phase 3)
KLN-1010 (Kelonia, in vivo CAR-T)Phase 1 (NCT07075185, relapsed or refractory multiple myeloma, estimated 70 participants, estimated primary completion March 2027)In development (Phase 1)
ORN-252 (Orna, in vivo CAR-T)Phase 1 (NCT07439796, 20 healthy adults, safety assessment, estimated primary completion December 2026). The 10-Q describes it as targeting CD19, for autoimmune disease involving B cellsIn development (Phase 1)
What could not be confirmed

None of the following appears in the disclosures Not yet confirmed.

The timing of approval filings for each product; dedicated R&D spending and headcount for genetic medicines; any in-house plan using iPS cells; and the Phase 3 results for Ixo-vec (the studies are still running). The main pipeline table in the 10-K for the end of 2025 does not list the earlier gene therapies from Prevail and Akouos (GBA1, GRN, OTOF), and their status cannot be confirmed from the 10-K.

8. What the company is aiming for

This section goes beyond what the company says directly. It sets out inferences that can be drawn from primary sources, each with its basis.

What can be readPrimary evidence behind itCategory
Lilly has chosen the route of rewriting genes, or making immune cells, inside the body rather than iPS cellsEvery product acquired is given in the body (gene editing, AAV, in vivo CAR-T). The 10-K and 10-Q do not mention iPS cellsInference (Sourced: the types of product acquired)
Its policy is to bring in new technology by acquisitionSix acquisitions between 2021 and 2026 (Prevail, Akouos, Verve, Adverum, Orna, Kelonia). No in-house start-up is describedInference (Sourced: the run of acquisitions)
The tilt towards in vivo CAR-T has strengthened sharply only recentlyOrna (US$1.233 billion) and Kelonia (US$4.897 billion) in May and June 2026. In the same period it issued US$9 billion of long-term debt, part of which is stated to fund the acquisitions of Centessa and KeloniaSourced (amounts and timing) / Inference (the tilt)
It is spreading its bets across areas where long-term safety is not yet establishedThree Phase 1 products and one Phase 3. Most are at an early stageInference
One inference, explained in full

The 10-Q states that between January and June 2026 Lilly spent US$13.3 billion on acquisitions including Centessa, Kelonia, Orna, Ventyx and Ajax Sourced. The two in vivo CAR-T companies (Orna and Kelonia) appear to account for a large share of that, but how much the company intends to invest in this field is not disclosed. In vivo CAR-T also solves the same problem by a different method from the off-the-shelf iPS cell-derived products: it removes the effort of making cells patient by patient. Which of the two reaches practical use depends on clinical results Not yet confirmed.

9. Map of acquisitions and partnerships

Lilly's acquisitions in genetic medicines Only ties in the Lilly, Verve and Adverum filings; press-reported ties are excluded Lilly Big pharma Verve Therapeutics Gene editing; bought July 2025 Adverum AAV gene therapy; bought Dec 2025 Kelonia Therapeutics In vivo CAR-T; bought June 2026 Orna Therapeutics In vivo CAR-T (ORN-252); May 2026 Prevail Therapeutics AAV9 gene therapy; bought Jan 2021 Akouos Inner-ear gene therapy; Dec 2022 Company acquired (solid) Asset purchase (dotted)
Fig. 2 Lilly's acquisitions of gene editing, gene therapy and in vivo CAR-T. Sources: Lilly's 10-K and 10-Q, and the 8-K filings of Verve and Adverum. Only relationships described in these disclosures are shown; relationships discussed in press coverage are left out. Orange solid lines are acquisitions of whole companies, and the dotted line is an asset purchase.

10. Technologies, products and services on offer

No product in this field has been approved. The technology platforms Lilly has acquired are as follows Sourced.

ItemWhat the disclosures say
VERVE-102 (gene editing)Designed to switch off the PCSK9 gene permanently in the liver. Delivered in Verve's own GalNAc-LNP (lipid nanoparticle). Uses base editing technology. Verve says the aim is to lower blood LDL cholesterol
Ixo-vec (AAV gene therapy)For neovascular age-related macular degeneration. Developed by Adverum and in Phase 3 (ARTEMIS and AQUARIUS)
KLN-1010 / ORN-252 (in vivo CAR-T)Therapies that give T cells the CAR inside the body. KLN-1010 is for multiple myeloma, and ORN-252 targets CD19 for autoimmune disease. The delivery method is not described in Lilly's disclosures
ManufacturingInvestment in a worldwide manufacturing network (capital expenditure of US$7.8 billion in 2025). No manufacturing facility dedicated to genetic medicines has been disclosed
A materials engineer's view: for in-body therapies, the "carrier" takes centre stage

VERVE-102 wraps the RNA of the editing enzyme and the guide RNA in a lipid nanoparticle (LNP) and delivers it to the liver (Verve's 10-Q says that the total dose of RNA in milligrams is becoming a key to pharmacodynamics) Sourced. On the materials side, four things matter: (1) RNA synthesis and purity (the editing enzyme mRNA and the guide RNA), (2) lipid quality (ionisable lipids, PEG lipids and so on, which govern particle stability and how well the particles reach the liver), (3) the mixing step that gives particles a uniform size, and single-use materials, and (4) freezing and storage conditions (see our explainers on lipid nanoparticles, mRNA and genome editing). With AAV products such as Ixo-vec, by contrast, manufacturing the viral vector (cell culture, purification and titre) tends to be the bottleneck, so the materials involved differ from those of cell therapies that process cells outside the body (see our explainers on viral vectors, GMP and CDMOs). Lilly does not disclose the specific materials or contract manufacturers it uses for each product Not yet confirmed.

11. The risks this company carries

RiskSubstanceCategory
Most products are early-stageIn vivo CAR-T is in Phase 1, gene editing in Phase 1b, and the only Phase 3 product is the AAV therapy Ixo-vecSourced
Long-term safety of gene editingEditing is a permanent change. Verve's 10-Q describes in vivo gene editing as a new technology whose safety and efficacy have not yet been established in the clinic. Verve discontinued the Heart-1 study of its earlier product, VERVE-101Sourced
Acquisition prices and performance conditionsCVRs and contingent consideration (up to US$3.75 billion for Kelonia) depend on results. Estimates made at acquisition may change. The 10-Q says the fair value calculation is provisional because limited information was available before the acquisitionSourced
The whole company depends on a few productsThe increase in revenue is mainly due to the diabetes and obesity medicines. Success or failure in genetic medicines would not weigh heavily on the company's overall resultsSourced (the dependence) / Inference (the effect)
Clean-up of earlier gene therapiesIn 2022 the company recorded an impairment of the intangible asset for an earlier product (the GBA1 gene therapy). Products from Prevail and Akouos are not listed in the main pipeline table at the end of 2025Sourced (the impairment) / not confirmed (what followed)
Thin knowledge of iPS cellsNo in-house plan for iPS cells or for cell therapy outside the body is disclosedInference

12. Glossary

Genome editing (gene editing)
A technology for rewriting DNA at a specific location. VERVE-102 uses base editing, which changes a base without cutting both DNA strands.
AAV
Adeno-associated virus. Used as a carrier (vector) to deliver genes into cells.
LNP (lipid nanoparticle)
A tiny particle that wraps RNA in lipids to deliver it to cells.
In vivo CAR-T
An approach in which T cells are given the CAR inside the body, without processing cells outside it.
PCSK9
A protein that affects the amount of LDL cholesterol in the blood. The gene that makes it is the editing target.
CVR (contingent value right)
Additional consideration paid after an acquisition only if specific results are achieved.
Acquired in-process R&D (IPR&D)
The price paid for an acquired asset still in development. In an asset acquisition it is recorded as an expense.
Asset acquisition versus business combination
In accounting, acquiring a whole business is a business combination and acquiring only assets is an asset acquisition, and the two are treated differently.
Form 10-K / 10-Q / 8-K
The annual, quarterly and current reports filed with the U.S. SEC.
Fig. 3 Concept diagram of the "rewrite genes inside the body" therapies Lilly has brought in (an AI-generated concept; it does not depict actual equipment or products).

13. References

  1. Eli Lilly and Company Form 10-K for the fiscal year ended December 31, 2025 (filed with the U.S. SEC on 12 February 2026). Revenue, R&D expenses, employees, the Verve acquisition and Ixo-vec. https://www.sec.gov/Archives/edgar/data/59478/000005947826000013/lly-20251231.htm
  2. Eli Lilly and Company Form 10-Q for the quarter ended June 30, 2026 (filed with the U.S. SEC on 5 August 2026). Kelonia, Orna and spending on business development. https://www.sec.gov/Archives/edgar/data/59478/000005947826000081/lly-20260630.htm
  3. Eli Lilly and Company Form 10-K for the fiscal year ended December 31, 2023 (filed with the U.S. SEC on 21 February 2024). The Prevail and Akouos acquisitions. https://www.sec.gov/Archives/edgar/data/59478/000005947824000065/lly-20231231.htm
  4. Verve Therapeutics Form 10-Q for the quarter ended March 31, 2025 (filed with the U.S. SEC on 14 May 2025). The research collaboration with Lilly, VERVE-102 and the early Heart-2 data. https://www.sec.gov/Archives/edgar/data/1840574/000095017025070911/verv-20250331.htm
  5. Verve Therapeutics Form 8-K (filed 17 June 2025). Terms of the merger agreement with Lilly. https://www.sec.gov/Archives/edgar/data/1840574/000119312525141748/d30505d8k.htm
  6. Verve Therapeutics Form 8-K (filed 25 July 2025). Completion of the tender offer. https://www.sec.gov/Archives/edgar/data/1840574/000119312525165462/d71385d8k.htm
  7. Adverum Biotechnologies Form 8-K (filed 24 October 2025). Terms of the merger agreement with Lilly. https://www.sec.gov/Archives/edgar/data/1501756/000119312525249438/d70157d8k.htm
  8. Adverum Biotechnologies Form 8-K (filed 9 December 2025). Completion of the tender offer. https://www.sec.gov/Archives/edgar/data/1501756/000119312525312722/d96637d8k.htm
  9. ClinicalTrials.gov NCT06164730 (VERVE-102, Phase 1b Heart-2). https://clinicaltrials.gov/study/NCT06164730
  10. ClinicalTrials.gov NCT07839936 (VERVE-102, Phase 2). https://clinicaltrials.gov/study/NCT07839936
  11. ClinicalTrials.gov NCT06856577 (Ixo-vec, Phase 3 ARTEMIS). https://clinicaltrials.gov/study/NCT06856577
  12. ClinicalTrials.gov NCT07482176 (Ixo-vec, Phase 3 AQUARIUS). https://clinicaltrials.gov/study/NCT07482176
  13. ClinicalTrials.gov NCT07075185 (KLN-1010, Phase 1). https://clinicaltrials.gov/study/NCT07075185
  14. ClinicalTrials.gov NCT07439796 (ORN252, Phase 1). https://clinicaltrials.gov/study/NCT07439796
  15. Eli Lilly and Company Official website, used to check the company name and logo. https://www.lilly.com/

14. Claim-to-source audit

Claim in the articleCategorySource
Legal name, head office, listing venue, about 50,000 employees (about 12,000 in R&D)SourcedReference 1 https://www.sec.gov/Archives/edgar/data/59478/000005947826000013/lly-20251231.htm
Revenue, net income, R&D expenses, acquired in-process R&D, capital expenditureSourcedReference 1 https://www.sec.gov/Archives/edgar/data/59478/000005947826000013/lly-20251231.htm
Terms of the Verve acquisition (US$549 million in cash, CVR of up to about US$300 million, July 2025) and that VERVE-102 is the main asset acquiredSourcedReference 1 https://www.sec.gov/Archives/edgar/data/59478/000005947826000013/lly-20251231.htm
Date of the Verve agreement (16 June 2025) and completion of the tender offer (July 2025)SourcedReferences 5 and 6 https://www.sec.gov/Archives/edgar/data/1840574/000119312525141748/d30505d8k.htm
The research collaboration with Verve (June 2023), the US$20 million milestone, IND acceptance and Fast Track for VERVE-102, and the early Heart-2 data (14 patients)SourcedReference 4 https://www.sec.gov/Archives/edgar/data/1840574/000095017025070911/verv-20250331.htm
Terms of the Adverum acquisition (US$3.56 per share plus a CVR of up to US$8.91) and completion (9 December 2025)SourcedReferences 7 and 8 https://www.sec.gov/Archives/edgar/data/1501756/000119312525249438/d70157d8k.htm
Ixo-vec is in Phase 3 and was acquired with AdverumSourcedReference 1 https://www.sec.gov/Archives/edgar/data/59478/000005947826000013/lly-20251231.htm
Orna (ORN-252, May 2026, US$1.233 billion) and Kelonia (KLN-1010, 25 June 2026, US$4.897 billion, contingent consideration of up to US$3.75 billion)SourcedReference 2 https://www.sec.gov/Archives/edgar/data/59478/000005947826000081/lly-20260630.htm
US$13.3 billion spent on business development in 2026, and the issue of US$9 billion of long-term debtSourcedReference 2 https://www.sec.gov/Archives/edgar/data/59478/000005947826000081/lly-20260630.htm
Terms of the Prevail acquisition (January 2021) and the Akouos acquisition (December 2022)SourcedReference 3 https://www.sec.gov/Archives/edgar/data/59478/000005947824000065/lly-20231231.htm
Design and primary endpoints of the VERVE-102 Heart-2 study (NCT06164730)SourcedReference 9 https://clinicaltrials.gov/study/NCT06164730
Design and planned start of the VERVE-102 Phase 2 study (NCT07839936)SourcedReference 10 https://clinicaltrials.gov/study/NCT07839936
Design of ARTEMIS (NCT06856577) and AQUARIUS (NCT07482176)SourcedReferences 11 and 12 https://clinicaltrials.gov/study/NCT06856577
Design of KLN-1010 (NCT07075185) and ORN252 (NCT07439796)SourcedReferences 13 and 14 https://clinicaltrials.gov/study/NCT07075185
That in vivo gene editing is a new technology not yet confirmed in the clinic, and the discontinuation of the Heart-1 study (VERVE-101)SourcedReference 4 https://www.sec.gov/Archives/edgar/data/1840574/000095017025070911/verv-20250331.htm
The 2022 impairment of the intangible asset for the GBA1 gene therapySourcedReference 3 https://www.sec.gov/Archives/edgar/data/59478/000005947824000065/lly-20231231.htm
That the fair value calculation for the Kelonia acquisition is provisionalSourcedReference 2 https://www.sec.gov/Archives/edgar/data/59478/000005947826000081/lly-20260630.htm
Confirmation of the logo and the way the name is writtenSourcedReference 15 https://www.lilly.com/
The three types of company in Fig. 1Our calculationOur own classification. Companies shown are examples from those covered in this series
Dedicated R&D spending, headcount and capital expenditure for genetic medicines, timing of approval filings, the delivery methods of Orna and Kelonia, and any in-house plan for iPS cellsNot yet confirmedNot in Lilly's disclosures. This article makes no estimate https://www.sec.gov/Archives/edgar/data/59478/000005947826000013/lly-20251231.htm
The reading that Lilly has chosen rewriting genes inside the body rather than iPS cellsInferenceThis article's interpretation of the types of product acquired and the absence of any mention of iPS cells
The reading that its policy is to bring in new technology by acquisitionInferenceThis article's interpretation of the run of acquisitions from 2021 to 2026
The reading that the tilt towards in vivo CAR-T has strengthened recentlyInferenceThis article's interpretation of the amounts acquired in May and June 2026
The reading that it is spreading its bets across early-stage products, and the view that success in genetic medicines is unlikely to weigh heavily on the whole companyInferenceThis article's interpretation of the distribution of development phases and the revenue mix

Last updated 1 October 2026 / Troy Technical
Every figure in this article comes from statutory filings made by Eli Lilly, Verve Therapeutics and Adverum Biotechnologies with the U.S. Securities and Exchange Commission, and from ClinicalTrials.gov. No research-firm estimates or press-based figures have been used. Passages marked "Inference" are this article's interpretation of primary sources, not statements made by the company. This article is not medical advice. It does not recommend any particular treatment or rank it against others.

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