New Technology– category –
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Kyverna’s miv-cel: Phase 1 data for progressive MS and RMAT status
BioSpace USA Overview Kyverna Therapeutics reported that a single dose of miv-cel achieved robust CNS penetration and improved disability scores in patients with progressive multiple sclerosis (PMS). The Phase 1 trial showed sustained cl... -
Osimertinib Cardiotoxicity: AMPK–LKB1 Signaling and iPSC Models
BIOENGINEER.ORG USA Overview Patient-derived iPSC cardiomyocytes reveal that susceptibility to osimertinib-induced cardiac dysfunction is linked to impaired AMPK–LKB1 signaling. Metformin cotreatment mitigated the decline in contraction ... -
SOD1 Gene Editing: Prime and Base Correction in Human iPSCs
BIOENGINEER.ORG USA Overview Researchers have successfully corrected two ALS-causing SOD1 mutations in human induced pluripotent stem cells (iPSCs) using prime and base editing. The study achieved correction efficiencies of approximately... -
Tetraploid iPS Cells: Enhancing Cardiac Function via Cell Fusion
Mirage News Japan Overview Researchers have established tetraploid human induced pluripotent stem (iPS) cells via cell fusion to create cardiomyocytes with enhanced functional capabilities. By replicating the natural chromosome doubling ... -
XellSmart XS411: Phase I iPSC Parkinson’s Therapy Results
Longevity.Technology USA Overview XellSmart's off-the-shelf cell therapy XS411 increased "good ON time" by an average of over five hours per day in nine Phase I patients. The treatment utilizes iPSC-derived dopamine neurons to target the... -
Nano24 EXO-CD24: Phase 2b ARDS mortality and efficacy results
BioPharm International USA Overview Inhaled EXO-CD24 significantly reduced 28-day mortality risk by 72% and shortened hospital stays in a phase 2b trial for acute respiratory distress syndrome (ARDS). The therapy achieved its primary end... -
AMSC-derived Exosomes: miR-26a-5p Mechanism in Kidney Fibrosis
Bioengineer.org USA Overview Researchers have identified that exosomes from adipose mesenchymal stem cells (AMSCs) halt kidney scarring by delivering miR-26a-5p to suppress the glycolysis regulator Pfkfb3. In mouse models, this treatment... -
HLHS iPSC-CMs: Mechanoadaptation defects and inflammatory response
bioRxiv USA Overview Human iPSC-derived cardiomyocytes (iPSC-CMs) from Hypoplastic Left Heart Syndrome (HLHS) patients exhibit maladaptive remodeling and heightened inflammatory signaling when exposed to cyclic stretch. Unlike control ce... -
PiggyBac CAR-T Engineering: Delivery Strategy Optimization 2026
bioRxiv Overview Researchers evaluated three piggyBac transposon delivery methods to optimize the cost-effective manufacturing of CAR-T cells. The study found that a one-plasmid system (ONE) provides the highest gene delivery efficiency,... -
Human Reprogramming: Epigenomic Heterogeneity and Spatial Organization
bioRxiv USA Overview Researchers integrated single-nucleus measurements and spatial transcriptomics to map the trajectories of human fibroblast reprogramming into induced pluripotent stem cells (iPSCs). The study reveals that productive ...
