New Technology– category –
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Vascularized Heart Organoids: hPSC-derived Soil-Seed System
bioRxiv Overview Researchers have developed a method to generate vascularized, chambered human cardiac organoids (hCOs) from human pluripotent stem cells (hPSCs) by recapitulating early heart-foregut development. This "Soil-Seed" system ... -
TAPBP Knockout: Reducing HLA Class I for Cardiac Cell Therapy
Bioengineer.org USA Overview Researchers in Japan have developed lab-grown heart cells that evade immune detection by knocking out the TAPBP gene using CRISPR-Cas9. These cardiomyocytes show reduced HLA class I expression, avoiding both ... -
XellSmart XS411: Phase I Results and Phase II Enrollment Status
PR Newswire South Korea・China Overview XellSmart reported Phase I results for XS411, an off-the-shelf iPSC-derived cell therapy for Parkinson's disease, showing motor function improvements exceeding MCID thresholds. The company also com... -
Dibucaine: Autophagic Flux and pS129 α-syn Reduction in PD
Frontiers Japan Overview Dibucaine, a local anesthetic, has been identified as a compound that induces autophagic flux and reduces Ser129-phosphorylated α-synuclein (pS129 α-syn) in human iPSC-derived neurons. This finding suggests a pot... -
USC GMP Platform: Renewable Immune Cell Supply for Cancer
Keck School of Medicine of USC / Science Daily USA Overview Scientists at the University of Southern California have developed a scalable platform using granulocyte-monocyte progenitors (GMPs) to create a renewable supply of engineered c... -
Aloe Vera Bioink: Immune-Smart 3D-Printed Bone Organoids Specs
Bioengineer.org USA Overview Researchers have developed a plant-based bioink using aloe vera to create 3D-printed bone organoids that actively regulate immune responses. The formulation promotes the shift of macrophages to a pro-regenera... -
CRL5 Pathway: UCLA’s Discovery to Prevent T-Cell Exhaustion
UCLA Health USA Overview UCLA researchers identified the Cullin-5 RING E3 ligase complex (CRL5) as a key molecular pathway driving T-cell exhaustion in cancer immunotherapy. Blocking this pathway allows engineered immune cells to maintai... -
Sonpiretigene isteparvovec: Optogenetic Therapy Phase 2 GA Trial
Eye Care Network - Ophthalmology Times USA Overview Nanoscope Therapeutics is planning a randomized phase 2 trial for sonpiretigene isteparvovec (son-vec) to treat geographic atrophy (GA), skipping a separate phase 1 safety study. Data f... -
RNA-guided transposition system: CRISPR alternative for 2026
BioTechniques (Cornell University) USA Overview Researchers have engineered a non-CRISPR gene editing system capable of inserting large DNA payloads with higher accuracy and efficiency than current methods. This tool allows for the repla... -
Prime Editing: Aarhus University’s GATA2 Deficiency Treatment
healthcare-in-europe.com (Aarhus University) Denmark Overview Researchers at Aarhus University have used prime editing to repair genetic defects in blood stem cells from patients with GATA2 deficiency. The process increased the proportio...
