in vitro– tag –
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Antibody-Drug Conjugates Prepared with Peptide Asparaginyl Ligase Enhance Uniformity and Antitumor Activity, Promising Pharmaceutical Applications
Molecular Cancer Therapeutics (AACR Journals) USA Overview Novel antibody-drug conjugates (ADCs) prepared using peptide asparaginyl ligase (PAL) demonstrated potent antitumor activity in both in vitro and in vivo models. This innovative ... -
Novel TROP2-Targeting ADC, hIMB1636-LDP-AE, Demonstrates Potent Antitumor Efficacy and Anti-Cancer Stem Cell Activity in Breast and Lung Cancers
Medium (@wuhanmabnus) China Overview A novel antibody-drug conjugate (ADC), hIMB1636-LDP-AE, engineered through genetic and molecular recombination technologies, has demonstrated potent antitumor efficacy in both in vitro and in vivo mod... -
Lonza Capsugel Pioneers Dual-Layer Strategy for Oral GLP-1 Delivery, Shielding Peptides from Enzymatic Attack
Capsugel (Lonza) Switzerland Overview Lonza Capsugel has engineered a novel dual-layer protection strategy to enable oral delivery of GLP-1 peptides, circumventing the critical challenge of enzymatic degradation within the gastrointestin... -
Transferrin-Conjugated Polymeric Nanoparticles via PISA Enhance BBB Transport and Doxorubicin Delivery for Glioblastoma Therapy
ACS Publications USA Overview Researchers have developed transferrin-conjugated polymeric nanoparticles, synthesized via polymerization-induced self-assembly (PISA), for enhanced blood-brain barrier (BBB) penetration and glioblastoma (GB... -
Efficient Prime Editing In Vivo and In Vitro Demonstrated with Lipid Nanoparticles: High Efficacy, Low Off-Target Effects
PubMed International Overview Recent research reports the development of an optimized platform for prime editing using lipid nanoparticles (PE-LNP), demonstrating high gene editing efficiency in vivo. This LNP-based system offers a compe... -
Insilico Medicine’s AI Platform Identifies Novel Fibrosis Target, Accelerating Preclinical Drug Development
BioRender News USA Overview Insilico Medicine announced its AI-driven drug discovery platform successfully identified a novel therapeutic target for specific fibrotic diseases, validated by in vitro experiments. This high-precision predi...
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