Lipid Nanoparticle– tag –
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siRNA Therapy Successfully Switches Off Harmful Genes: FDA-Approved Patisiran and Other Drugs for Hereditary Amyloidosis
Works in Progress Magazine UK Overview siRNA therapy is emerging as a promising treatment to slow or halt disease progression by temporarily silencing specific genes. For conditions like hereditary transthyretin amyloidosis, FDA-approved... -
Journal of the American Chemical Society Reports Photochemistry-Based Lipid Library Significantly Improves mRNA-LNP Delivery In Vivo
Journal of the American Chemical Society USA Overview A study in the Journal of the American Chemical Society reports the development of a photochemistry-based ionizable lipid library (PILL) platform for rapid discovery of ionizable lipi... -
NUS Medicine and Tianjin Medical University Develop Bioinspired LNP Gene Therapy, Achieving Over 20% Cholesterol Reduction by Targeting PCSK9 Gene in Liver
Technology Networks Singapore/China Overview Researchers from NUS Medicine and Tianjin Medical University General Hospital have developed a bioinspired lipid nanoparticle (LNP) capable of delivering gene-editing machinery to the liver. T... -
Frontiers in Highlights AI and Machine Learning for LNP Design, Accelerating Advanced Drug Delivery System Development
Frontiers in International Overview This article discusses how AI and machine learning are revolutionizing the design and screening of lipid nanoparticle (LNP) formulations for advanced drug delivery systems. AI can predict LNP propertie... -
Review Highlights PLGA and LNP Nanomaterials as Key to Inducing Transplantation Tolerance, Improving Targeted Delivery and Sustained Release
Frontiers in Immunology International Overview A review in *Frontiers in Immunology* outlines advances in nanomaterial-based delivery systems for inducing transplantation tolerance. Polylactic-co-glycolic acid (PLGA) polymeric nanopartic... -
Nagoya University & FUJIFILM Develop FL0445-LNP, Enhancing Circular RNA Activity Tenfold with Negligible Inflammation for Longer-Lasting mRNA Treatments
Clinical Lab Japan Overview Researchers at Nagoya University and FUJIFILM Corporation have developed a new lipid nanoparticle (LNP), FL0445-LNP, for delivering circular RNA (cirRNA) into cells. This system improves mRNA activity tenfold ... -
CRISPR Frontiers 2026: Innovations in DSB-Independent Editing and Delivery Systems Boost Genome Editing Precision and Stability
Addgene Blog USA Overview The 'Genome Engineering: CRISPR Frontiers 2026' conference reported significant evolution in CRISPR technology towards precise, double-strand break (DSB)-independent editing. Researchers are focusing on enhancin... -
Next-Generation CRISPR Tools Revolutionize Precise Gene Editing, Bypassing Double-Strand Breaks for Enhanced Therapeutic Safety and Consistency
News-Medical.net USA Overview Next-generation CRISPR technologies are fundamentally transforming cell and gene therapy by enabling precise gene editing without relying on double-strand DNA breaks (DSBs). Advances in base editing, prime e... -
Nagoya University and Fujifilm Jointly Develop Novel LNP Delivery System for Enhanced Cyclic RNA Therapeutics
EurekAlert! Japan Overview Researchers from Nagoya University and Fujifilm have jointly developed a novel lipid nanoparticle (LNP) delivery system designed for efficient and stable intracellular delivery of circular RNA (cirRNA), a promi... -
Precision Lipid Nanoparticles Target Solid Tumors, Spare Healthy Tissue; University of Tokyo System Achieves 10x Concentration
KU Leuven Belgium Overview Researchers at Belgium's Leuven University have engineered novel lipid nanoparticles (LNPs) for targeted chemotherapy in solid tumors. These LNPs selectively bind to protein markers on malignant cells, preventi...
