Proteasome– tag –
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BMS Molecular Glue Mezigdomide Combination Therapy Transforms Oncology: Achieves 52% Reduction in Progression or Death Risk in Phase 3 Multiple Myeloma Trial
PMLiVE Unknown Overview Targeted protein degraders (TPDs), specifically PROTACs and molecular glues, are rapidly advancing in oncology. At ASCO, Bristol Myers Squibb (BMS) announced Phase 3 results showing their molecular glue, Mezigdomi... -
BMS Reveals Promising Clinical Data for Next-Gen Blood Cancer Therapy Mezigdomide
BioPharma Dive USA Overview Bristol Myers Squibb (BMS) unveiled promising new clinical data for mezigdomide, its next-generation blood cancer therapy. This drug is one of two key protein degradation inducers BMS expects to succeed its mu... -
Arvinas Accelerates Clinical Development of ARV-027 for Kennedy’s Disease, Targeting Mutant Androgen Receptor Degradation with PROTAC
Kennedy's Disease Association USA Overview Arvinas is steadily advancing the clinical development of ARV-027, an investigational PROTAC degrader for Kennedy's Disease (Spinal and Bulbar Muscular Atrophy, SBMA). ARV-027 is designed to sel... -
Nature Chemical Biology Reports Discovery of Novel E3 Ligase Modulators Opening Path to Intractable Protein Degradation
Nature Chemical Biology USA Overview A new study in Nature Chemical Biology identified novel E3 ligase modulators that can extend the scope of targeted protein degradation (TPD) to a new class of disease-related proteins. This discovery ... -
Kymera Therapeutics Initiates Phase 1 Clinical Trial for Oral STAT3 Degrader KT-XXX
Kymera Therapeutics Press Release USA Overview Kymera Therapeutics has announced the initiation of a Phase 1 clinical trial for its lead STAT3 degrader candidate, KT-XXX. The study aims to evaluate the safety, pharmacokinetics (PK), and ...
