New Technology– category –
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Ac-FL-020: Phase 1 safety and PSA decline data for mCRPC (2026)
PR Newswire（Full-Life Technologies） USA Overview Full-Life Technologies reported preliminary Phase 1 data for [ 225 Ac]Ac-FL-020, showing 100% PSA50 in lutetium-177-naive mCRPC patients at dose levels 6 to 8 MBq. The study demonstrated... -
Arrowhead ARO-MAPT: Tau reduction data and BBB platform vs Biogen
BioSpace USA Overview Arrowhead Pharmaceuticals' siRNA candidate ARO-MAPT achieved up to 85% reduction in CSF tau levels in healthy volunteers, according to Phase 1/2a data. Analysts suggest the platform's ability to bypass the blood-bra... -
Avian Gene Editing: LNP-Mediated Delivery for Embryo Phenotypes
bioRxiv USA Overview Researchers have established a lipid nanoparticle (LNP) delivery platform for high-efficiency gene editing and phenotype generation in avian embryos. By optimizing LNP formulations, the team achieved somatic genome e... -
cGAS-STING/IL-12 mRNA LNPs: Systemic Tumor Control Strategy
bioRxiv USA Overview Researchers have developed an mRNA lipid nanoparticle (LNP) platform that co-delivers an autoactivated cGAS mutant (R241E) and membrane-tethered IL-12 (IL-12TM) to induce systemic antitumor immunity. The combination ... -
MA2 Molecular Glue: MDA5 Agonist for Innate Immunity Stimulation
bioRxiv USA Overview Researchers have identified MA2, a first-in-class selective MDA5 agonist that functions as a dynamic molecular glue to enhance innate immune signaling. By targeting a plastic interface within MDA5 filaments, MA2 pote... -
AlphaFold 3 vs BANDOCK+: Benchmarking Drug Discovery Scores
bioRxiv Overview AlphaFold 3 (AF3) demonstrates potential for computational drug discovery, achieving slightly higher aggregate disease ranking scores than BANDOCK+ in a 1,103 protein comparison. However, BANDOCK+ provides significantly ... -
RFD4-Proteina: Nvidia and UW’s Open-Source Protein Design AI
Genetic Engineering & Biotechnology News USA Overview Nvidia and the University of Washington's Institute for Protein Design (IPD) have released RFD4-Proteina, an open-source generative AI model for functional protein design. The model a... -
Cellular Nanodiscs: Size-Dependent Bioactivity and Drug Delivery
Technology Networks USA Overview Researchers from the University of California San Diego found that shrinking cellular nanodiscs significantly improves their ability to bind biological targets and neutralize bacterial toxins. By comparin... -
SCA3 Therapy: Targeted ASOs Cut Toxic Ataxin-3 by 90%
Technology Networks Germany Overview Researchers have developed targeted antisense oligonucleotides (ASOs) that reduce disease-causing Ataxin-3 by approximately 90% in human neurons while preserving normal protein levels. This approach u... -
RPT04402 Molecular Glue: Stabilizing PP2A to Suppress Cancer
Technology Networks USA Overview University of Michigan researchers have demonstrated that the molecular glue RPT04402 stabilizes the tumor-suppressing protein PP2A to inhibit cancer growth. The treatment showed efficacy in reducing tumo...
