Modality– tag –
-
Antibody-Drug Conjugates (ADCs) Show Promise for Epithelioid Hemangioendothelioma (EHE) Treatment: Highlighted at ASCO 2026
EHE Foundation USA Overview Antibody-drug conjugates (ADCs) are gaining significant attention as a promising emerging strategy for treating epithelioid hemangioendothelioma (EHE), a rare and challenging cancer. ADCs deliver potent anti-c... -
BMS Molecular Glue Mezigdomide Combination Therapy Transforms Oncology: Achieves 52% Reduction in Progression or Death Risk in Phase 3 Multiple Myeloma Trial
PMLiVE Unknown Overview Targeted protein degraders (TPDs), specifically PROTACs and molecular glues, are rapidly advancing in oncology. At ASCO, Bristol Myers Squibb (BMS) announced Phase 3 results showing their molecular glue, Mezigdomi... -
BMS Reveals Promising Clinical Data for Next-Gen Blood Cancer Therapy Mezigdomide
BioPharma Dive USA Overview Bristol Myers Squibb (BMS) unveiled promising new clinical data for mezigdomide, its next-generation blood cancer therapy. This drug is one of two key protein degradation inducers BMS expects to succeed its mu... -
Novartis’ Acquired RNA Therapeutic del-brax Achieves Phase 1/2 Success for Muscle-Wasting Diseases
BioPharma Dive USA Overview Novartis' RNA therapeutic del-brax, acquired through its $12 billion purchase of Avidity Pharmaceuticals, successfully completed a Phase 1/2 clinical trial for muscle-wasting diseases, achieving its primary en... -
Arvinas Accelerates Clinical Development of ARV-027 for Kennedy’s Disease, Targeting Mutant Androgen Receptor Degradation with PROTAC
Kennedy's Disease Association USA Overview Arvinas is steadily advancing the clinical development of ARV-027, an investigational PROTAC degrader for Kennedy's Disease (Spinal and Bulbar Muscular Atrophy, SBMA). ARV-027 is designed to sel... -
Nature Biotechnology Reports Novel Therapeutic Modality of Circular RNA for Cancer Treatment
Nature Biotechnology Unknown Overview A groundbreaking study published in Nature Biotechnology explores the therapeutic potential of engineered circular RNA molecules in cancer treatment. The research demonstrates that specific circular ... -
Daiichi Sankyo Records Significant Loss Due to ADC Supply ‘Miscalculation’ Despite Strong Enhertu Sales, Raising Risk Management Questions
東洋経済オンライン Japan Overview Japanese pharmaceutical giant Daiichi Sankyo reported a substantial operating profit decrease for FY2025 despite record sales, attributing a 169.5 billion yen loss provision to compensation for Antibody-... -
siRNA Therapeutics: Advancements in Chemical Modification and Targeted Delivery Expand Clinical Horizons Beyond the Liver
MDPI Global Overview siRNA therapeutics are achieving significant clinical success driven by sophisticated chemical modifications and robust delivery systems. GalNAc conjugates have become the gold standard for liver-targeted therapies, ...
12