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Pfizer Discontinues Seagen-Developed Solid Tumor ADC Program SGN-MesoC2, Highlighting Persistent ADC Development Challenges
BioSpace USA Overview Pfizer has discontinued another Seagen-developed antibody-drug conjugate (ADC) program for solid tumors, SGN-MesoC2, just weeks after another Seagen-acquired ADC failed a Phase 3 lung cancer study. This cessation un... -
Antibody-Drug Conjugates Show Significant Clinical Activity and Promise in Biliary Tract Cancers
CCA News Online USA Overview Antibody-drug conjugates (ADCs) are emerging as a significant class of cancer therapeutics for biliary tract cancers (BTCs), offering improved outcomes in difficult-to-treat tumors. Advances in ADC technology... -
ASCO Podcast: Optimizing Frontline ADCs as They Shift to Earlier Cancer Treatment Stages
ASCO Publications USA Overview An ASCO Publications podcast discusses the rapid integration of antibody-drug conjugates (ADCs) into frontline advanced and curative-intent perioperative settings for cancer treatment. Experts emphasize tha... -
Optimized NAMPT Inhibitors Enable Highly Effective ADCs for Liquid and Solid Tumors, Achieving Complete Regressions in Preclinical Models
ACS Bio & Med Chem Au USA Overview This publication details the development of next-generation NAMPT inhibitors as ADC payloads through physicochemical and metabolic optimization. When conjugated to anti-CD30, anti-HER2, or anti-TROP2 an... -
Modular In Vivo Antibody-ADC Click Strategy Reverses Drug Resistance in Tumors
PubMed (Nature Chemical Biology) USA Overview Researchers have introduced an in vivo bioorthogonal ligation strategy to generate functional antibody-drug conjugate (ADC) click constructs following systemic administration. This modular pl... -
Optimal Payload Linker Selection is Critical for ADC Development, Balancing Efficacy, Safety, and Stability
Chemexpress China Overview This guide highlights the critical role of selecting the right payload linker for successful antibody-drug conjugate (ADC) programs. Linker design dictates the balance between efficacy, safety, stability, and m... -
NIH-Funded Team Discovers Miniaturized CRISPR Enzyme Al3Cas12f, Enabling Precision In Vivo Gene Delivery via AAV Vectors
National Institutes of Health (NIH) USA Overview An NIH-funded research team has discovered a novel, enhanced miniaturized CRISPR gene-editing system, a natural enzyme named 'Al3Cas12f,' capable of targeted in vivo delivery. This enzyme ... -
NASA Contracts Astrobotic, Intuitive Machines, Firefly for Lunar Cargo, Explores ‘PROMISE’ Nuclear Rover for Moon Base Development
SpaceQ USA Overview NASA has awarded approximately $600 million in new contracts to Astrobotic, Intuitive Machines, and Firefly for lunar scientific payload delivery in late 2028, aiming to establish a sustained human presence on the Moo... -
Preprint Released on arXiv: Dual-Satellite Coordinated Soft X-Ray Polarimetry CubeSat Electronics System Design Detailed
arXiv Global Overview A preprint has been published on arXiv detailing the design of a high-reliability CubeSat payload electronics system for dual-satellite coordinated soft X-ray polarimetry. This system integrates a Gas Micro-channel ... -
China Successfully Lands Long March-10B First Stage, Pioneering Reusable Rocket Technology and Drastically Cutting Launch Costs
Business Insider China Overview China has achieved a groundbreaking milestone in reusable rocket technology by successfully recovering the first stage of its new Long March-10B rocket. This success is a critical step for China's ambition...
