New Technology– category –
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Focused Ultrasound Blood-Brain Barrier Opening: Remote Metabolic Response Discovered in Primate Brain Raises Clinical Application Challenges
PubMed (National Library of Medicine) USA Overview Low-intensity focused ultrasound (LIFU) is a promising technology for blood-brain barrier (BBB) opening for drug delivery, yet a study in non-human primate models revealed unexpected rem... -
FDA Approval a TPD Turning Point? Maria Soloveychik Cautions Single Molecule Success Doesn’t Guarantee All Targets
Drug Discovery Online USA Overview Maria Soloveychik acknowledges the FDA approval of a bivalent degrader as a crucial 'proof point' for the Targeted Protein Degradation (TPD) field but warns that this single molecular success does not n... -
Verseon Champions Physics-Based Molecular Design to Transcend AI’s Training Data in Drug Discovery
Endpoints News USA Overview Verseon asserts that physics-based molecular design can reach chemical spaces beyond the limitations of traditional screening and generative AI training data, opening untapped drug discovery realms. Their Deep... -
FDA Approves Dato-DXd (Datroway) for Metastatic Triple-Negative Breast Cancer based on Phase III TROPION-Breast02 Trial
Cancer Network USA Overview The U.S. FDA has approved datopotamab deruxtecan-dlnk (Dato-DXd; Datroway) for adult patients with unresectable or metastatic triple-negative breast cancer (TNBC) who are ineligible for PD-1/PD-L1 immune check... -
EMD Serono’s Investigational Enpatoran Granted FDA Breakthrough Therapy Designation for Active Cutaneous Lupus
Lupus Foundation of America USA Overview EMD Serono's investigational drug enpatoran has received Breakthrough Therapy Designation from the U.S. FDA for the treatment of systemic lupus erythematosus (SLE) with active cutaneous manifestat... -
Breaking the Blood-Brain Barrier: Nanoparticles Chart New Course for Neurodegenerative Therapies
Dove Medical Press New Zealand Overview The blood-brain barrier (BBB) prevents over 98% of small-molecule drugs and nearly all biologics from entering the brain, posing a major challenge for neurological therapies. Nanoparticles (NPs) of... -
UT MD Anderson Tackles Brain Tumor Therapy by Advancing Multiple Blood-Brain Barrier Penetration Strategies
UT MD Anderson Cancer Center USA Overview Researchers at UT MD Anderson Cancer Center are aggressively pursuing multiple research strategies to overcome the blood-brain barrier (BBB), a formidable challenge in brain tumor treatment. Whil... -
Boehringer Ingelheim’s First-in-Class Obesity Drug BI 3034701 Enters Phase II, Triggers €10M Milestone Payment to Gubra
Boehringer Ingelheim Germany Overview Boehringer Ingelheim has initiated a Phase II clinical trial for BI 3034701, a potential first-in-class GLP-1/GIP/NPY2 triple receptor agonist for patients with obesity and overweight. This investiga... -
From Noise to Novel 3D Molecules: Diffusion Models Transform Drug Design AI
Google Cloud Vertex AI Search USA Overview Diffusion models, a breakthrough AI methodology successful in image generation, are now being applied to molecular structure generation for drug design. These models generate new molecules by pr... -
Large Models Reshape Chemistry: Generative AI Drives Novel Molecular Design in Drug Discovery
Google Cloud Vertex AI Search USA Overview Generative AI is fundamentally transforming drug chemistry by creating novel molecular structures rather than merely screening existing ones. These large machine learning models learn patterns o...
