Blood-Brain Barrier– tag –
-
Breakthrough: EU Approves Oral BTK Inhibitor Tolebrutinib as First Disability-Targeting Therapy for Nonrelapsing SPMS
NeurologyLive Europe Overview The European Commission has approved Sanofi's oral, brain-penetrant Bruton's tyrosine kinase (BTK) inhibitor, tolebrutinib (Cenrifki), for nonrelapsing secondary progressive multiple sclerosis (SPMS). This a... -
Denali Therapeutics Advances DNL628 (MAPT-Targeting ASO) for Neurodegenerative Diseases, DNL593 for GRN FTD Granted Orphan Drug Designation
Seeking Alpha USA Overview Denali Therapeutics is progressing DNL628, an intravenously administered ASO designed to reduce tau by targeting MAPT, with initial Phase 1b biomarker data expected in H1 2027 from its TransportVehicle platform... -
Focused Ultrasound Dramatically Enhances Brain Tumor Drug Delivery: Mid-Sized Molecules Most Effective, Ushering in a New Era of Non-Invasive Therapy
Neuroscience News USA Overview New research shows focused ultrasound (FUS) combined with microbubbles is highly effective for targeted drug delivery to primary brain tumors (gliomas). This non-invasive technique temporarily and reversibl... -
Transferrin-Conjugated Polymeric Nanoparticles via PISA Enhance BBB Transport and Doxorubicin Delivery for Glioblastoma Therapy
ACS Publications USA Overview Researchers have developed transferrin-conjugated polymeric nanoparticles, synthesized via polymerization-induced self-assembly (PISA), for enhanced blood-brain barrier (BBB) penetration and glioblastoma (GB... -
Montara Therapeutics Reimagines Blood-Brain Barrier as Solution, Not Problem, Secures $1M for Brain-Selective mTOR Therapy
Drug Discovery News USA Overview Montara Therapeutics is pioneering an approach to blood-brain barrier (BBB) drug delivery by leveraging the BBB to its advantage for brain-selective pharmacology. Instead of forcing drugs across, their te... -
Organ-on-Chip Platforms Accelerate Nanoparticle DDS Development: Revolutionizing Preclinical Predictive Power
Biophysics Reviews | AIP Publishing USA Overview While nanoparticle-based drug delivery systems (DDS) have advanced significantly, their preclinical evaluation's predictive power has been a bottleneck. The integration of nanoparticles wi... -
Nanotechnology Revolutionizes Cancer Treatment: EPR Effect Enables Tumor-Selective Drug Delivery and Reduced Toxicity
HCG Oncology India Overview Nanotechnology is revolutionizing cancer treatment by delivering therapeutic drug doses to tumors while minimizing collateral damage to healthy tissue. Nano-drugs, engineered within nanocarrier platforms like ... -
UVA Health Breakthrough: Focused Ultrasound Breaches Blood-Brain Barrier for Glioma Treatment, Identifies Optimal Drug Size
UVA Health USA Overview Researchers at UVA Health discovered that gliomas are more receptive to targeted drug delivery via focused ultrasound than normal brain tissue. This technique uses microbubbles activated by sound waves to temporar... -
Low-Intensity Focused Ultrasound and Microbubbles Temporarily Open Blood-Brain Barrier, Unlocking Brain Drug Delivery
Drug Target Review UK Overview Researchers are investigating low-intensity focused ultrasound (LIFU) combined with intravenously administered microbubbles to temporarily and reversibly increase the permeability of the blood-brain barrier... -
Focused Ultrasound and Microbubbles Temporarily Open Blood-Brain Barrier for Enhanced Brain Drug Delivery
Drug Target Review UK Overview The blood-brain barrier (BBB) obstructs most therapeutic agents from reaching the brain, a major hurdle in treating neurological disorders. Researchers are advancing focused ultrasound (FUS), specifically l...
