in vivo– tag –
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Patient-Specific iPSCs in Organ-on-a-Chip Systems: Pioneering Personalized Medicine and Drug Testing
PMC International Overview Organ-on-a-chip (OoC) systems innovatively mimic human organ structures and functions at a micro-scale. Induced pluripotent stem cells (iPSCs) serve as an ideal platform for constructing patient-specific OoC mo... -
In Vivo CAR-T Cell Therapy Demonstrates Clinical Proof-of-Concept with AI Acceleration: Enabling Direct In-Body Immune Cell Gene Editing Towards ‘Off-the-Shelf Biologics’
OncoDaily International Overview While autologous CAR-T cell therapy yields durable remissions in B-cell malignancies, its delivery model faces persistent challenges. In vivo CAR-T emerges as a radically different approach, delivering CA... -
AstraZeneca Accelerates Next-Gen Cell Therapy Manufacturing: Gracell’s Rapid Platform Reduces Autologous CAR T Production Time
AstraZeneca UK Overview AstraZeneca is addressing critical challenges in cell therapy by accelerating autologous cell therapy manufacturing and advancing allogeneic and in vivo 'off-the-shelf' approaches. Notably, they are leveraging Gra... -
Azunic AI Adopts Inventia Life Science’s RASTRUM 3D Cell Culture Platform to Accelerate Human-Relevant In Vitro Toxicology
BusinessWire USA Overview Azunic AI has adopted Inventia Life Science's RASTRUM 3D cell culture platform to accelerate the development of an animal-free, human-relevant 3D in vitro toxicology platform. RASTRUM's precision bioprinting, de... -
In Vivo CAR T-Cell Therapy KLN-1010 Achieves 100% MRD Negativity in Multiple Myeloma Phase 1 Trial, Presented at ASCO/EHA 2026
International Myeloma Foundation USA Overview At the 2026 ASCO and EHA meetings, groundbreaking results for KLN-1010, an in vivo CAR T-cell therapy eliminating the need for ex vivo T-cell harvest, were highlighted. The clinical trial in ... -
Human Methacryloyl Platelet Lysate Hydrogels Emerge as Robust Xeno-Free Platform for 3D Cell Culture and Tissue Engineering
PMC (National Library of Medicine) USA Overview Novel xeno-free human methacryloyl platelet lysate (hPLMA) hydrogels have been developed, demonstrating robust and reproducible performance in 3D cell culture and tissue engineering applica... -
Single-Day Manufactured IL-18-Armed CAR T Cells Demonstrate Durable Anti-Tumor Efficacy and Exhaustion Resistance
Blood - ASH Publications USA Overview Researchers have developed a novel single-day manufacturing process for nonactivated IL-18-armed CAR T cells, exhibiting potent anti-tumor efficacy and enhanced persistence in both in vitro and in vi... -
Rice University Engineers Harness Electrostatic Charge for Weeks-Long Controlled Peptide Release, Revolutionizing Regenerative Medicine
Rice University USA Overview Engineers at Rice University have developed a novel strategy to precisely control the release of therapeutic peptides from gelatin-based materials. By adjusting the peptide's electrical charge, the team signi... -
Lonza Capsugel Pioneers Dual-Layer Strategy for Oral GLP-1 Delivery, Shielding Peptides from Enzymatic Attack
Capsugel (Lonza) Switzerland Overview Lonza Capsugel has engineered a novel dual-layer protection strategy to enable oral delivery of GLP-1 peptides, circumventing the critical challenge of enzymatic degradation within the gastrointestin... -
Nanoparticle Breakthroughs: Piercing the Blood-Brain Barrier to Revolutionize CNS Disease Treatment, Including Glioblastoma
MDPI Switzerland Overview Nanoparticle-based drug delivery systems are emerging as a pivotal solution for overcoming the blood-brain barrier (BBB), a critical challenge in treating central nervous system (CNS) diseases. A recent review h...
