Endress+Hauser Boosts Single-Use Bioprocessing with Innovative Proline Promass U 500 Coriolis Flowmeter, Integrating Reusable Units with Disposable Sensors for Enhanced Flexibility

August 17, 2026

Endress+Hauser Switzerland

Overview

Endress+Hauser announced the Proline Promass U 500 Coriolis flowmeter as the latest innovation in single-use technology for bioprocessing. This groundbreaking technology combines a reusable base unit with a disposable sensor assembly, delivering sterile design and high-accuracy measurements for mass flow, density, and temperature. This is expected to enhance flexibility in scaling biologics, cell, and gene therapies, significantly contributing to process efficiency and product quality stabilization.

In Depth

Key Findings

Endress+Hauser has introduced the Proline Promass U 500 Coriolis flowmeter as the latest innovation in single-use technology for bioprocessing. This groundbreaking device combines a reusable base unit with a disposable sensor assembly, enabling high-precision measurement of mass flow, density, and temperature in sterile processes, thereby significantly enhancing flexibility and efficiency in the manufacturing of biopharmaceuticals, cell, and gene therapies.

Technical / Clinical Details

The Proline Promass U 500 is a high-precision flowmeter that directly measures the mass flow of fluids using the Coriolis effect. Its key feature is that the sensing element is provided as a disposable plastic assembly. This single-use sensor assembly is supplied gamma-sterilized and can be easily attached to a reusable electronic base unit. This design offers the following significant benefits:

**Sterile Design**: As the parts in direct contact with the process fluid are disposable, the risk of cross-contamination is completely eliminated, ensuring sterility in GMP (Good Manufacturing Practice) environments.
**High-Precision Measurement**: Simultaneous and highly accurate measurement of mass flow, density, and temperature provides essential data for optimizing process control and ensuring product quality consistency.
**Flexibility and Rapid Changeover**: Eliminating the need for cleaning and sterilization processes between batches significantly reduces product or batch changeover times, improving manufacturing line uptime and flexibility.
**Enhanced Scalability**: Provides consistent measurement performance across various scales, from R&D to clinical trials and commercial production, facilitating the scale-up of biopharmaceuticals, cell, and gene therapy products.

This technology has the potential to contribute to cost reduction and efficiency improvement, especially in the manufacturing of expensive cell and gene therapies.

Background & Context

The manufacturing of biopharmaceuticals, particularly cell and gene therapies, constantly demands innovative manufacturing technologies due to its complexity, high costs, and stringent regulatory requirements. Traditional reusable stainless steel equipment requires extensive time and resources for cleaning and sterilization, and cannot completely eliminate the risk of cross-contamination. In contrast, single-use technology has rapidly gained traction in the biomanufacturing industry as an effective approach to address these challenges. The introduction of products by leading process measurement instrument manufacturers like Endress+Hauser that align with this trend is crucial for driving overall industry efficiency and sustainability.

Strategic Significance & Outlook

The advent of the Proline Promass U 500 Coriolis flowmeter will further enhance the reliability and performance of single-use bioprocessing, expanding its range of applications. This technology will contribute to reducing biopharmaceutical costs, shortening time-to-market, and stabilizing supply, ultimately leading to delivering innovative therapies to more patients. In the future, such hybrid single-use solutions are expected to become standard measurement technologies in the biomanufacturing industry, accelerating the realization of more intelligent and autonomous manufacturing processes through integration with AI and automation systems. Investors are keenly observing how the evolution of single-use technology addresses biomanufacturing bottlenecks and creates new growth opportunities.

Source: https://www.us.endress.com/en/endress-hauser-group/press-center/news-and-press-releases/What-are-the-latest-innovations-in-single-use-technology-for-bioprocessing

Get our weekly technology intelligence — free

Receive an infographic that lets you judge at a glance whether each field’s analysis report is worth reading.

Subscribe Free — Weekly Tech Intelligence

By subscribing, you’ll receive Troy-Technical’s weekly technology intelligence newsletter.