Chromatography– tag –
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Continuous Multi-Column Chromatography Integrates and Intensifies Monoclonal Antibody Downstream Processing, Boosting Efficiency and Sustainability
BioProcess International USA Overview The integration of two chromatography steps using a continuous multi-column chromatography (MCC) system is shown to dramatically improve the efficiency and sustainability of downstream processing in ... -
Continuous Chromatography & ICH Q13 Overcome Downstream Purification Challenges Amplified by Upstream Intensification
Separation Science Global Overview According to Separation Science, upstream bioreactor intensification, including N-1 perfusion seeding and high-density fed-batch, is creating new challenges for downstream purification. Continuous purif... -
Separation Science Reports AI-Assisted Protein A Chromatography Optimization for mAb Purification: Real-Time Predictive Control Enhances Yield and Purity
Separation Science USA Overview Separation Science reports on a breakthrough application of AI and machine learning (ML) in optimizing Protein A chromatography for monoclonal antibody (mAb) purification. AI models accurately predict dyna... -
AI and Machine Learning Revolutionize Biologics Purification: Optimizing Monoclonal Antibody Manufacturing with Predictive Resin Life and Enhanced Yields
Separation Science UK Overview Artificial intelligence (AI) and machine learning (ML) are significantly optimizing purification processes for biologics, contributing to cost reduction and yield enhancement in monoclonal antibody (mAb) ma... -
Data Integrity in Bioprocessing: ALCOA+ Compliance Critical for Ensuring Reliability of GMP Records
Lab Manager Global Overview In bioprocessing labs, data integrity and adherence to ALCOA+ principles are critical for meeting regulatory expectations and ensuring product safety and efficacy. All GMP records, including those from bioreac... -
Data Integrity and ALCOA+ Compliance Critical for Bioprocessing Lab Managers: Addressing Regulatory Requirements with Digital Solutions
LabManager.com USA Overview An article highlights the critical importance of data integrity and ALCOA+ compliance for bioprocessing lab managers. Maintaining ALCOA+ (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, C... -
Lonza Presents Optimization Strategies to Address Purity and Potency Challenges in In Vivo Lentiviral Vector Development for Cell and Gene Therapies
Biocompare Switzerland Overview Lonza outlined optimization strategies for lentiviral vector (LVV) development for in vivo delivery of cell and gene therapies. Key challenges in LVV development include achieving purity, complexity of val... -
Cytiva Achieves Enhanced mAb Variant Separation and Purity Using IEX and Multimodal Resins, Optimizing Elution pH with Capto SP ImpRes
Cytiva USA Overview Cytiva's latest research demonstrates a significant improvement in separating charged monoclonal antibody (mAb) variants and achieving higher purity using ion exchange (IEX) and multimodal resins. Specifically, optimi...
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