Lipid Nanoparticle– tag –
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Machine Learning Accelerates Lipid Nanoparticle Design, Streamlining RNA Therapeutic Formulation Development for High Efficacy and Reduced Experimental Burden
Pharmatica USA Overview Machine learning (ML) is being applied to lipid nanoparticle (LNP) design to accelerate formulation development, improve delivery performance, and reduce experimental burden for RNA therapeutics, gene-editing syst... -
Comprehensive Guide to Lipid Nanoparticles (LNPs): Key to mRNA Vaccine Success and Future RNA Therapeutic Delivery
Inside Therapeutics USA Overview Lipid nanoparticles (LNPs) are crucial nanodrug delivery systems for nucleic acids like mRNA and siRNA, vital for mRNA vaccine success and RNA therapeutics. This guide details LNP composition (ionizable l... -
MDPI Accelerates Non-Coding RNA Cancer Therapy with Organ-Selective LNPs: Achieving Precise Delivery to Liver, Spleen, and Lung
MDPI Switzerland Overview Non-coding RNA (ncRNA) therapeutics in cancer are advancing, with their efficacy significantly influenced by lipid nanoparticle (LNP) characteristics like lipid composition, particle size, and surface charge. Re... -
ACE Therapeutics’ LNP Gene Editing Platform Achieves Over 90% Hepatocyte Selectivity for Lipoprotein-Targeted Cardiovascular Therapeutics
ACE Therapeutics USA Overview ACE Therapeutics' LNP-delivered gene editing platform achieves over 90% efficient hepatocyte-selective delivery for lipoprotein-targeted cardiovascular therapeutics, minimizing extrahepatic editing risks. Th... -
Backbone-Ionized Polymer iPβAE Quantitatively Guides Extra-Hepatic mRNA Expression to Spleen and Lung
Journal of the American Chemical Society USA Overview A study published in the Journal of the American Chemical Society introduces a backbone-ionized polymer (iPβAE) platform engineered for quantitatively guided extra-hepatic mRNA target... -
Mannosylated Spleen-Targeted LNP (LNP-PAM) Enhances mRNA Delivery to Antigen-Presenting Cells, Overcoming Liver Tropism
ACS Publications USA Overview A novel mannosylated spleen-targeted lipid nanoparticle (LNP-PAM) has been developed to significantly enhance mRNA delivery to antigen-presenting cells by integrating active and endogenous targeting. This sy... -
Organ-on-Chip Platforms Accelerate Nanoparticle DDS Development: Revolutionizing Preclinical Predictive Power
Biophysics Reviews | AIP Publishing USA Overview While nanoparticle-based drug delivery systems (DDS) have advanced significantly, their preclinical evaluation's predictive power has been a bottleneck. The integration of nanoparticles wi... -
Viral Vector CDMO Capacity Exceeds Clinical Demand: Catalent and Lonza Lead AAV Manufacturing Expansion
IntuitionLabs USA Overview An August 2026 analyst report reveals that viral vector manufacturing capacity, especially for AAV, has outpaced current clinical demand, offering gene therapy sponsors more options and competitive lead times. ... -
LNP Design Innovations Enable Extrahepatic Nucleic Acid Delivery: Paving Way for Mucosal Administration Routes
MDPI Switzerland Overview Recent breakthroughs in lipid nanoparticle (LNP) design, driven by altered formulation composition and chemical modification of ionizable lipids, are enabling organ-selective nucleic acid delivery beyond the liv... -
Bioengineering Strategies Overcome Liver Tropism to Improve Cardiac Targeting of LNPs for Heart Disease Therapy
Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals USA Overview Despite promise in cardiovascular disease treatment, nanomedicines face challenges of insufficient cardiac targeting and poor retention...
